Clinical Pediatric Emergency Medicine
Volume 6, Issue 2 , Pages 85-92 , June 2005

Pediatric Dietary Supplement Use—An Update

  • Kavita M. Babu, MD

      Affiliations

    • Division of Toxicology, Department of Emergency Medicine, University of Masschusetts Medical School, Worcester, MA, 01655 USA
    • Corresponding Author InformationReprint requests and correspondence: Kavita M. Babu, MD, Division of Toxicology, Department of Emergency Medicine, University of Worcester, MA.
  • ,
  • Mary A. McCormick, PharmD, DABAT

      Affiliations

    • Drugmax/Arrow-Familymeds, Farmington, CT 06032
  • ,
  • Steven B. Bird, MD

      Affiliations

    • Division of Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA

References 

  1. Eisenberg DM, Davis RB, Ettner SL, et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA. 1998;280:1569–1575
  2. Palmer ME, Haller C, McKinney PE, et al. Adverse events associated with dietary supplements: an observational study. Lancet. 2003;361:101–106
  3. Ernst E. Adverse effects of herbal drugs in dermatology. Br J Dermatol. 2000;143:923–929
  4. Jordan S, Murty M, Pilon K. Products containing bitter orange or synephrine: suspected cardiovascular adverse reactions. Can Med Assoc J. 2004;171:993–994
  5. Mullins RJ, Heddle R. Adverse reactions associated with echinacea: the Australian experience. Ann Allergy Asthma Immunol. 2002;88:42–51
  6. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med. 2000;343:1833–1838
  7. Pfaffenrath V, Diener HC, Fischer M, et al. The efficacy and safety of Tanacetum parthenium (feverfew) in migraine prophylaxis—a double-blind, multicentre, randomized placebo-controlled dose-response study. Cephalalgia. 2002;22:523–532
  8. Miller LG. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158:2200–2211
  9. Rose KD, Croissant PD, Parliament CF, et al. Spontaneous spinal epidural hematoma with associated platelet dysfunction from excessive garlic ingestion: a case report. Neurosurgery. 1990;26:880–882
  10. Hodges PJ, Kam PC. The peri-operative implications of herbal medicines. Anaesthesia. 2002;57:889–899
  11. Rosenblatt M, Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med. 1997;336:1108
  12. Miller LG, Freeman B. Possible subdural hematoma associated with Ginkgo biloba. J Herb Pharmacother. 2002;2:57–63
  13. Hopkins MP, Androff L, Benninghoff AS. Ginseng face cream and unexplained vaginal bleeding. Am J Obstet Gynecol. 1988;159:1121–1122
  14. Kiefer D, Pantuso T. Panax ginseng. Am Fam Phys. 2003;68:1539–1542
  15. Chatterjee P, Franklin MR. Human cytochrome P450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos. 2003;31:1391–1397
  16. Stickel F, Baumuller HM, Seitz K, et al. Hepatitis induced by kava (Piper methysticum rhizoma). J Hepatol. 2003;39:62–67
  17. Almeida JC, Grimsley EW. Coma from the health food store: interaction between kava and alprazolam. Ann Intern Med. 1996;125:940–941
  18. Anke J, Ramzan I. Pharmacokinetic and pharmacodynamic drug interactions with kava (Piper methysticum Forst f). J Ethnopharmacol. 2004;93:153–160
  19. Zhou S, Chan E, Pan SQ, et al. Pharmacokinetic interactions of drugs with St John's wort. J Psychopharmacol. 2004;18:262–276
  20. Knuppel L, Linde K. Adverse effects of St. John's Wort: a systematic review. J Clin Psychiatr. 2004;65:1470–1479
  21. Hadley S, Petry JJ. Valerian. Am Fam Phys. 2003;67:1755–1758
  22. Lanski SL, Greenwald M, Perkins A, et al. Herbal therapy use in a pediatric emergency department population: expect the unexpected. Pediatrics. 2003;111:981–985
  23. Sanders H, Davis MF, Duncan B, et al. Use of complementary and alternative medical therapies among children with special health care needs in southern Arizona. Pediatrics. 2003;111:584–587
  24. Leung JM, Dzankic S, Manku K, et al. The prevalence and predictors of the use of alternative medicine in presurgical patients in five California hospitals. Anesth Analg. 2001;93:1062–1068
  25. Spigelblatt L, Laine-Ammara G, Pless IB, et al. The use of alternative medicine by children. Pediatrics. 1994;94:811–814
  26. Trigazis L, Tennankore D, Vohra S, et al. The use of herbal remedies by adolescents with eating disorders. Int J Eat Disord. 2004;35:223–228
  27. Wilson KM, Klein JD. Adolescents' use of complementary and alternative medicine. Ambul Pediatr. 2002;2:104–110
  28. Yussman SM, Ryan SA, Auinger P, et al. Visits to complementary and alternative medicine providers by children and adolescents in the United States. Ambul Pediatr. 2004;4:429–435
  29. Dietary Supplement Health and Education Act, in 103, 1994, vol. 417
  30. Rados C. Ephedra Ban: no shortage of reasons. March-April ed In: FDA consumer magazine. vol. 2004:2004;
  31. Kinariwala N. Tighter regulation needed for dietary supplements in USA. Lancet. 2003;361:1566
  32. Ko RJ. Adulterants in Asian patent medicines. N Engl J Med. 1998;339:847
  33. Ernst E, Thompson Coon J. Heavy metals in traditional Chinese medicines: a systematic review. Clin Pharmacol Ther. 2001;70:497–504
  34. Moore C, Adler R. Herbal vitamins: lead toxicity and developmental delay. Pediatrics. 2000;106:600–602
  35. Bose A, Vashistha K, O'Loughlin BJ. Azarcon por empacho—another cause of lead toxicity. Pediatrics. 1983;72:106–108
  36. Leads from the MMWR . Folk remedy-associated lead poisoning in Hmong children. JAMA. 1983;250:3149–3150
  37. Kang-Yum E, Oransky SH. Chinese patent medicine as a potential source of mercury poisoning. Vet Hum Toxicol. 1992;34:235–238
  38. Andrews L, Lokuge S, Sawyer M, et al. The use of alternative therapies by children with asthma: a brief report. J Paediatr Child Health. 1998;34:131–134
  39. Southwood TR, Malleson PN, Roberts-Thomson PJ, et al. Unconventional remedies used for patients with juvenile arthritis. Pediatrics. 1990;85:150–154
  40. Stern RC, Canda ER, Doershuk CF. Use of nonmedical treatment by cystic fibrosis patients. J Adolesc Health. 1992;13:612–615
  41. Pitetti R, Singh S, Hornyak D, et al. Complementary and alternative medicine use in children. Pediatr Emerg Care. 2001;17:165–169
  42. Kelly KM, Jacobson JS, Kennedy DD, et al. Use of unconventional therapies by children with cancer at an urban medical center. J Pediatr Hematol Oncol. 2000;22:412–416
  43. Coppes MJ, Anderson RA, Egeler RM, et al. Alternative therapies for the treatment of childhood cancer. N Engl J Med. 1998;339:846–847
  44. Heuschkel R, Afzal N, Wuerth A, et al. Complementary medicine use in children and young adults with inflammatory bowel disease. Am J Gastroenterol. 2002;97:382–388
  45. Metzl JD, Small E, Levine SR, et al. Creatine use among young athletes. Pediatrics. 2001;108:421–425
  46. Congeni J, Miller S. Supplements and drugs used to enhance athletic performance. Pediatr Clin North Am. 2002;49:435–461
  47. Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med. 1999;340:814–815
  48. Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet. 1998;351:1252–1253
  49. Ahrendt DM. Ergogenic aids: counseling the athlete. Am Fam Phys. 2001;63:913–922
  50. Brush DE, Bird SB, Boyer EW. Monoamine oxidase inhibitor poisoning resulting from Internet misinformation on illicit substances. J Toxicol Clin Toxicol. 2004;42:191–195
  51. Administration FaD. Warning on herbal street drug alternatives? FDA updates—May-June 2004, in FDA consumer, vol. 2004.
  52. Halpern JH. Hallucinogens and dissociative agents naturally growing in the United States. Pharmacol Ther. 2004;102:131–138
  53. De Smet PA. Health risks of herbal remedies: an update. Clin Pharmacol Ther. 2004;76:1–17
  54. Slifman NR, Obermeyer WR, Aloi BK, et al. Contamination of botanical dietary supplements by Digitalis lanata. N Engl J Med. 1998;339:806–811
  55. Chan TY. Incidence of herb-induced aconitine poisoning in Hong Kong: impact of publicity measures to promote awareness among the herbalists and the public. Drug Safe. 2002;25:823–828
  56. US Food and Drug Administration CfFSaAN. FDA advises dietary supplement manufacturers to remove comfrey products from the market, in, July 6, 2001.
  57. Chitturi S, Farrell GC. Herbal hepatotoxicity: an expanding but poorly defined problem. J Gastroenterol Hepatol. 2000;15:1093–1099
  58. Bakerink JA, Gospe SM, Dimand RJ, et al. Multiple organ failure after ingestion of pennyroyal oil from herbal tea in two infants. Pediatrics. 1996;98:944–947
  59. Nortier JL, Vanherweghem JL. Renal interstitial fibrosis and urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). Toxicology. 2002;181-182:577–580
  60. Wojcikowski K, Johnson DW, Gobe G. Medicinal herbal extracts – renal friend or foe? Part one: the toxicities of medicinal herbs. Nephrology (Carlton). 2004;9:313–318
  61. Subat-Dezulovic M, Slavic I, Rozmanic V, et al. Drug-induced acute tubulointerstitial nephritis: a case with elevated urinary cadmium. Pediatr Nephrol. 2002;17:382–385
  62. Glover DD, Amonkar M, Rybeck BF, et al. Prescription, over-the-counter, and herbal medicine use in a rural, obstetric population. Am J Obstet Gynecol. 2003;188:1039–1045
  63. Mbura JS, Mgaya HN, Heggenhougen HK. The use of oral herbal medicine by women attending antenatal clinics in urban and rural Tanga district in Tanzania. East Afr Med J. 1985;62:540–550
  64. Conover EA. Herbal agents and over-the-counter medications in pregnancy. Best Pract Res Clin Endocrinol Metab. 2003;17:237–251
  65. Jang EH, Park YC, Chung WG. Effects of dietary supplements on induction and inhibition of cytochrome P450s protein expression in rats. Food Chem Toxicol. 2004;42:1749–1756
  66. Lee A, Chui PT, Aun CS, et al. Possible interaction between sevoflurane and Aloe vera. Ann Pharmacother. 2004;38:1651–1654
  67. Ang-Lee MK, Moss J, Yuan CS. Herbal medicines and perioperative care. JAMA. 2001;286:208–216
  68. Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: a systematic review. Drugs. 2001;61:2163–2175
  69. Zink T, Chaffin J. Herbal ‘health’ products: what family physicians need to know. Am Fam Phys. 1998;58:1133–1140

PII: S1522-8401(05)00053-4

doi: 10.1016/j.cpem.2005.04.003

Clinical Pediatric Emergency Medicine
Volume 6, Issue 2 , Pages 85-92 , June 2005