Clinical Pediatric Emergency Medicine
Volume 6, Issue 4 , Pages 207-215 , December 2005

Pediatric Advanced Life Support Update for Emergency Department Physicians

  • William W. Hammill, MD

      Affiliations

    • Division of Pediatric Cardiology, Department of Pediatrics, University of Virginia Health System, Charlottesville, VA
    • Cardiopulmonary and Vascular Services, Martha Jefferson Hospital, Charlottesville, VA
    • Corresponding Author InformationReprint requests and correspondence: William W. Hammill, MD, Division of Pediatric Cardiology, Department of Pediatrics, University of Virginia Health System, 459 Locust Ave, Charlottesville, VA 22902.
    • ,
  • Janet Butler, BA

      Affiliations

    • Consultant J & H Associates, Charlottesville, VA

References 

  1. Brimacombe J. The advantages of the LMA over the tracheal tube or facemask: a meta-analysis. Can J Anaesth. 1995;42:1017–1023
  2. Berry AM, Brimacombe JR, Verghese C. The laryngeal mask airway in emergency medicine, neonatal resuscitation, and intensive care medicine. Int Anesthesiol Clin. 1998;36:91–109
  3. Lopez-Gil M, Brimacombe J, Cebrian J, et al. Laryngeal mask airway in pediatric practice: a prospective study of skill acquisition by anesthesia residents. Anesthesiology. 1996;84:807–811
  4. Lopez-Gil M, Brimacombe J, Alvarez M. Safety and efficacy of the laryngeal mask airway: a prospective survey of 1400 children. Anaesthesia. 1996;51:969–972
  5. Paterson SJ, Byrne PJ, et al. Neonatal resuscitation using the laryngeal mask airway. Anesthesiology. 1994;80:1248–1253
  6. Gandini D, Brimacombe JR. Neonatal resuscitation with the laryngeal mask airway in normal and low birth weight infants. Anesth Analg. 1999;89:642–643
  7. Bhende MS, Thompson AE, Orr RA. Utility of an end-tidal carbon dioxide detector during stabilization and transport of critically ill children. Pediatrics. 1992;89:1042–1044
  8. Bhende MS, Thompson AE, Cook DR, et al. Validity of a disposable end-tidal CO2 detector in verifying endotracheal tube placement in infants and children. Ann Emerg Med. 1992;21:142–145
  9. Bhende MS, Thompson AE. Evaluation of an end-tidal CO2 detector during pediatric cardiopulmonary resuscitation. Pediatrics. 1995;95:395–399
  10. Ornato JP, Shipley JB, Racht EM, et al. Multicenter study of a portable, hand-size, colorimetric end-tidal carbon dioxide detection device. Ann Emerg Med. 1992;21:518–523
  11. Ward KR, Yealy DM. End-tidal carbon dioxide monitoring in emergency medicine, 2: clinical applications. Acad Emerg Med. 1998;5:637–646
  12. Kern KB, Sanders AB, Voorhees WD, et al. Changes in expired end-tidal carbon dioxide during cardiopulmonary resuscitation in dogs: a prognostic guide for resuscitation efforts. J Am Coll Cardiol. 1989;13:1184–1189
  13. Callaham M, Barton C. Prediction of outcome of cardiopulmonary resuscitation from end-tidal carbon dioxide concentration. Crit Care Med. 1990;18:358–362
  14. Levine RL, Wayne MA, Miller CC. End-tidal carbon dioxide and outcome of out-of-hospital cardiac arrest. N Engl J Med. 1997;337:301–306
  15. Varon AJ, Morrina J, Civetta JM. Clinical utility of a colorimetric end-tidal CO2 detector in cardiopulmonary resuscitation and emergency intubation. J Clin Monit. 1991;7:289–293
  16. Kasper CL, Deem S. The self-inflating bulb to detect esophageal intubation during emergency airway management. Anesthesiology. 1998;88:898–902
  17. Zaleski L, Abello D, Gold MI. The esophageal detector device: does it work?. Anesthesiology. 1993;79:244–247
  18. Haynes SR, Morton NS. Use of the esophageal detector device in children under one year of age. Anaesthesia. 1990;45:1067–1069
  19. Sharieff GQ, Rodarte A, Wilton N, et al. The self-inflating bulb as an airway adjunct: is it reliable in children weighing less than 20 kilograms?. Acad Emerg Med. 2003;10:303–308
  20. Lindner KH, Pfenninger EG, Lurie KG, et al. Effects of active compression-decompression resuscitation on myocardial and cerebral blood flow in pigs. Circulation. 1993;88:1254–1263
  21. Chang MW, Coffeen P, Lurie KG, et al. Active compression-decompression CPR improves vital organ perfusion in a dog model of ventricular fibrillation. Chest. 1994;106:1250–1259
  22. Shultz JJ, Coffeen P, Sweeny M, et al. Evaluation of standard and active compression-decompression CPR in an acute human model of ventricular fibrillation. Circulation. 1994;89:684–693
  23. Chang FC, Harrison PB, Beech RR, et al. PASG: does it help in the management of traumatic shock?. J Trauma. 1995;39:453–456
  24. Mattox KL, BIckell W, Pepe PE, et al. Prospective MAST study in 911 patients. J Trauma. 1989;29:1104–1111
  25. Aprahamian C, Gessert G, Bandyk DF, et al. MAST-associated compartment syndrome (MACS): a review. J Trauma. 1989;29:549–555
  26. Blomquist S, Aberg T, Solem JO, et al. Lung mechanics, gas exchange and central circulation during treatment of intra-abdominal hemorrhage with pneumatic anti-shock garment and intra-aortic balloon occlusion: an experimental study in pigs. Eur Surg Res. 1994;26:240–247
  27. Bircher N, Safar P. Manual open-chest cardiopulmonary resuscitation. Ann Emerg Med. 1984;13:770–773
  28. Boczar ME, Howard MA, Rivers EP, et al. A technique revisited: hemodynamic comparison of closed- and open-chest cardiac massage during human cardiopulmonary resuscitation. Crit Care Med. 1995;23:498–503
  29. Redding JS, Cozine RA. A comparison of open-chest and closed-chest cardiac massage in dogs. Anesthesiology. 1961;22:280–285
  30. Sheikh A, Brogan T. Outcome and cost of open- and closed-chest cardiopulmonary resuscitation in pediatric cardiac arrests. Pediatrics. 1994;93:392–398
  31. Niemann JT, Criley JM, Rosborough JP, et al. Predictive indices of successful cardiac resuscitation after prolonged arrest and experimental cardiopulmonary resuscitation. Ann Emerg Med. 1985;14:521–528
  32. Otto C, Yakaitis R, Blitt C. Mechanism of action of epinephrine in resuscitation from asphyxial arrest. Crit Care Med. 1981;9:321–324
  33. Huang YG, Wong KC, Yip WH, et al. Cardiovascular responses to graded doses of three catecholamines during lactic and hydrochloric acidosis in dogs. Br J Anaesth. 1995;74:583–590
  34. Brow CG, Werman HA. Adrenergic agonists during cardiopulmonary resuscitation. Resuscitation. 1990;19:1–16
  35. Gonzales ER, Ornato JP, Garnet AR, et al. Dose-dependent vasopressor responses to epinephrine during CPR in human beings. Ann Emerg Med. 1998;18:920–926
  36. Goetting MG, Paradis NA. High-dose epinephrine improves outcome from pediatric cardiac arrest. Ann Emerg Med. 1991;20:22–26
  37. Brown CG, Martin DR, Pepe PE , et al. the Multicenter High-Dose Epinephrine Study Group A comparison of standard-dose and high-dose epinephrine in cardiac arrest outside the hospital. N Engl J Med. 1992;327:1051–1055
  38. Callaham M, Madsen CD, Barton CW, et al. A randomized trial of high-dose epinephrine and norepinephrine versus standard dose epinephrine in prehospital cardiac arrest. JAMA. 1992;268:2667–2672
  39. Lipman J, Wilson W, Kobilski S, et al. High-dose adrenaline in adult in-hospital asystolic cardiopulmonary resuscitation: a double-blind randomised trial. Anaesth Intensive Care. 1993;21:192–196
  40. Lindner KH, Ahnefeld FW, Prengel AW. Comparison of standard and high-dose adrenaline in the resuscitation of asystole and electromechanical dissociation. Acta Anaesthesiol Scand. 1991;35:253–256
  41. Sherman BW, Munger MA, Foulke GE, et al. High-dose versus standard-dose epinephrine treatment of cardiac arrest after failure of standard therapy. Pharmacotherapy. 1997;17:242–247
  42. Berg RA, Otto CW, Kern KB, et al. High-dose epinephrine results in greater early mortality after resuscitation from prolonged cardiac arrest in pigs: a prospective, randomized study. Crit Care Med. 1994;22:282–290
  43. Berg RA, Otto CW, Kern KB, et al. A randomized, blinded trial of high-dose epinephrine versus standard-dose epinephrine in a swine model of pediatric asphyxial cardiac arrest. Crit Care Med. 1996;24:1695–1700
  44. Carpenter TC, Stenmark KR. High-dose epinephrine is not superior to standard-dose epinephrine in pediatric in-hospital cardiopulmonary arrest. Pediatrics. 1997;99:403–408
  45. Dieckmann RA, Vardis R. High-dose epinephrine in pediatric out-of-hospital cardiopulmonary arrest. Pediatrics. 1995;95:901–913
  46. Rivers EP, Wortsman J, Rady MY, et al. The effect of the total cumulative epinephrine dose administered during human CPR on hemodynamic, oxygen transport, and utilization variables in the postresuscitation period. Chest. 1994;106:1499–1507
  47. Tan W, Weil MH, Sun S, et al. Epinephrine increases the severity of postresuscitation myocardial dysfunction. Circulation. 1995;92:3089–3093
  48. Perondi M, Reis A, Paiva FF, et al. A comparison of high-dose and standard-dose epinephrine in children with cardiac arrest. N Engl J Med. 2004;350:1722–1730
  49. Lindner KH, Prengel AW, Pfenninger EG, et al. Vasopressin improves vital organ blood flow during closed-chest cardiopulmonary resuscitation in pigs. Circulation. 1995;91:215–221
  50. Prengel AW, Lindner KH, Keller A. Cerebral oxygenation during cardiopulmonary resuscitation with epinephrine and vasopressin in pigs. Stroke. 1996;27:1241–1248
  51. Biondi-Zoccai GG, Abbate A, Parisi Q, et al. Is vasopressin superior to adrenaline or placebo in the management of cardiac arrest? A meta-analysis. Resuscitation. 2003;59:221–224
  52. Mann K, Berg RA, Nadkarni V. Beneficial effects of vasopressin in prolonged pediatric cardiac arrest: a case series. Resuscitation. 2002;52:149–156
  53. Voelckel WG, Lurie KG, McKnite S, et al. Effects of epinephrine and vasopressin in a piglet model of prolonged ventricular fibrillation and cardiopulmonary resuscitation. Crit Care Med. 2002;30:957–962
  54. Nozari A, Rubertsson S, Wiklund L. Differences in the pharmacodynamics of epinephrine and vasopressin during and after experimental cardiopulmonary resuscitation. Resuscitation. 2001;49:59–72
  55. Banai S, Tzivoni D. Drug therapy for torsades de pointes. J Cardiovasc Electrophysiol. 1993;4:206–210
  56. Fazekas T, Scherlag BJ, Vos M, et al. Magnesium and the heart: antiarrhythmic therapy with magnesium. Clin Cardiol. 1993;16:768–774
  57. van Haarst AD, van 't Klooster GA, van Gerven JM, et al. The influence of cisapride and clarithromycin on QT intervals in healthy volunteers. Clin Pharmacol Ther. 1998;64:542–546
  58. Losek JD, Endom E, Dietrich A, et al. Adenosine and pediatric supraventricular tachycardia in the emergency department: multicenter study and review. Ann Emerg Med. 1999;33:185–191
  59. Overholt E, Rheuban K, Gutgesell H, et al. Usefulness of adenosine for arrhythmias in infants and children. Am J Cardiol. 1988;61:336–340
  60. Getschman SJ, Dietrich AM, Franklin WH, et al. Intraosseous adenosine: as effective as peripheral or central venous administration?. Arch Pediatr Adolesc Med. 1994;148:616–619
  61. Bauthier J, Broekhuysen J, Charlier R, et al. Nature of the inhibition by amiodarone of isoproterenol-induced tachycardia in the dog. Arch Int Pharmacodyn Ther. 1976;219:45–51
  62. Kosinski EJ, Albin JB, Young E, et al. Hemodynamic effects of intravenous amiodarone. J Am Coll Cardiol. 1984;4:565–570
  63. Singh BN. Amiodarone: historical development and pharmacologic profile. Am Heart J. 1983;106:788–797
  64. Yabek SM, Kato R, Singh BN. Effects of amiodarone and its metabolite, desethylamiodarone, on the electrophysiologic properties of isolated cardiac muscle. J Cardiovasc Pharmacol. 1986;8:197–207
  65. Mattioni TA, Zheutlin TA, Dunnington C, et al. The proarrhythmic effects of amiodarone. Prog Cardiovasc Dis. 1989;31:439–446
  66. Mason JW, Hondeghem LM, Katzung BG. Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone. Circ Res. 1984;55:278–285
  67. Raja P, Hawker RE, Chaikitpinyo A, et al. Amiodarone management of junctional ectopic tachycardia after cardiac surgery in children. Br Heart J. 1994;72:261–265
  68. Figa FH, Gow RM, Hamilton RM, et al. Clinical efficacy and safety of intravenous amiodarone in infants and children. Am J Cardiol. 1994;74:573–577
  69. Perry JC, Fenrich AL, Hulse JE, et al. Pediatric use of intravenous amiodarone: efficacy and safety in critically ill patients from a multicenter protocol. J Am Coll Cardiol. 1996;27:1246–1250
  70. Perry JC, Knilans TK, Marlow D, et al. Intravenous amiodarone for life-threatening tachyarrhythmias in children and young adults. J Am Coll Cardiol. 1993;22:95–98
  71. Pongiglione G, Strasburger JF, Deal BJ, et al. Use of amiodarone for short-term and adjuvant therapy in young patients. Am J Cardiol. 1991;68:603–608
  72. Scheinman MM, Levine JH, Cannom DS, et al. Dose-ranging study of intravenous amiodarone in patients with life-threatening ventricular tachyarrhythmias. Circulation. 1995;92:3264–3272
  73. Raeder EA, Podrid PJ, Lown B. Side effects and complications of amiodarone therapy. Am Heart J. 1985;109:975–983
  74. Nademanee K, Piwonka RW, Singh BN, et al. Amiodarone and thyroid function. Prog Cardiovasc Dis. 1989;31:427–437
  75. Gutgesell HP, Tacker WA, Geddes LA, et al. Energy dose for ventricular defibrillation of children. Pediatrics. 1976;58:898–901
  76. Chameides L, Brown GE, Raye JR, et al. Guidelines for defibrillation in infants and children: report of the American Heart Association target activity group: cardiopulmonary resuscitation in the young. Circulation. 1977;56:502A–503A
  77. Cummins RO, Hazinski MF, Kerber RE, et al. Low-energy biphasic waveform defibrillation: evidence-based review applied to emergency cardiovascular care guidelines: a statement for healthcare professionals from the American Heart Association Committee on Emergency Cardiovascular Care and the Subcommittees on Basic Life Support, Advanced Cardiac Life Support, and Pediatric Resuscitation. Circulation. 1998;97:1654–1667
  78. Berg RA, Chapman FW, et al. Relationship between defibrillation dosage and outcome in a swine model of pediatric ventricular fibrillation. Circulation. 2003;108(17 Suppl IV):IV380–IV381
  79. Clark CB, Zhang Y, Davies LR, et al. Pediatric transthoracic defibrillation: biphasic versus monophasic waveforms in an experimental model. Resuscitation. 2001;51:159–163
  80. Killingsworth CR, Melnick SB, Chapman FW, et al. Defibrillation threshold and cardiac responses using an external biphasic defibrillator with pediatric and adult adhesive patches in pediatric-sized piglets. Resuscitation. 2002;55:177–185
  81. Rossano JW, Quan L, Schiff MA, et al. Survival is not correlated with defibrillation dosing in pediatric out-of-hospital ventricular fibrillation. Circulation. 2003;108(17 Suppl IV):IV320–IV321
  82. Atkins DL, Hartley LL, York DK. Accurate recognition and effective treatment of ventricular fibrillation by automated external defibrillators in adolescents. Pediatrics. 1998;101:393–397
  83. Cecchin F, Perry JC, Berul CI, et al. Accuracy of automatic external defibrillator analysis algorithm in young children. Circulation. 1999;100(Suppl I):I-663;[Abstract]
  84. Hazinski MF, Walker C, Smith H, et al. Specificity of automatic external defibrillator rhythm analysis in pediatric tachyarrhythmias. Circulation. 1997;96(Suppl I):I-561
  85. Tang W, Weil MH, Jorgenson D, et al. Fixed-energy biphasic waveform defibrillation in a pediatric model of cardiac arrest and resuscitation. Crit Care Med. 2002;30:2736–2741
  86. Samson R, Berg R, Bingham R, et al. PALS Task Force ILCOR advisory statement. Use of automated external defibrillators for children: an update. Circulation. 2003;107:3250–3255
  87. Beland MJ, Hesslein PS, Finlay CD, et al. Noninvasive transcutaneous cardiac pacing in children. Pacing Clin Electrophysiol. 1987;10:1262–1270
  88. Quan L, Graves JR, Kinder DR, et al. Transcutaneous cardiac pacing in the treatment of out-of-hospital pediatric cardiac arrests. Ann Emerg Med. 1992;21:905–909
  89. Falk RH, Ngai ST. External cardiac pacing: influence of electrode placement on pacing threshold. Crit Care Med. 1986;14:931–932
  90. Oral H, Brinkman K, Pelosi F, et al. Effect of electrode polarity on the energy required for transthoracic atrial defibrillation. Am J Cardiol 1999;84:228-230, A8.

PII: S1522-8401(05)00113-8

doi: 10.1016/j.cpem.2005.09.009

Clinical Pediatric Emergency Medicine
Volume 6, Issue 4 , Pages 207-215 , December 2005

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