Clinical Pediatric Emergency Medicine
Volume 9, Issue 1 , Pages 4-16, March 2008

Management of Beta-Adrenergic Blocker Poisoning

  • Angela C. Anderson, MD, FAAP

      Affiliations

    • Corresponding Author InformationReprint requests and correspondence: Angela C. Anderson, MD, FAAP, Pediatric Emergency Medicine, Hasbro Children's Hospital, Providence, RI.

Pediatric Emergency Medicine, Hasbro Children's Hospital, Providence, RI 02903

Warren Alpert Medical School of Brown University, Providence, RI

Beta-adrenergic blocking agents or β-blockers are prescribed for the treatment of a broad array of common disorders. Their widespread use, coupled with a narrow therapeutic index, contributes to their being a significant cause of poisoning from overdose and the second most common cause of mortality from cardiovascular agents. This article provides an overview of beta-adrenergic system pathophysiology and the properties and pharmacokinetics of β-blockers. Also discussed are the various effects and management of β-blockers in overdose settings.

Keywords: β-blockers, poisoning, cardiovascular agents, overdose

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PII: S1522-8401(07)00098-5

doi:10.1016/j.cpem.2007.12.001

Clinical Pediatric Emergency Medicine
Volume 9, Issue 1 , Pages 4-16, March 2008

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