Clinical Pediatric Emergency Medicine
Volume 9, Issue 1 , Pages 35-42 , March 2008

Energy Drinks: The New Eye-Opener For Adolescents

  • Kavita M. Babu, MD

      Affiliations

    • Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts, Worcester, MA
    • Corresponding Author InformationReprint requests and correspondence: Kavita M. Babu, MD, Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts, Worcester, MA.
  • ,
  • Richard James Church, MD

      Affiliations

    • Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts, Worcester, MA
  • ,
  • William Lewander, MD

      Affiliations

    • Division of Pediatric Emergency Medicine, Department of Emergency Medicine, Brown Medical School/Hasbro Children's Hospital, Providence, RI 01655

References 

  1. Shute N. Over the limit?. US News and World Report. Available at: http://health.usnews.com/usnews/health/articles/070415/23caffeine.htmPosted April 15, 2007. [Accessed September 15, 2007]
  2. Foxnews.com . Teens abusing energy boosting drinks, doctors fear. Available at: http://www.foxnews.com/story/0,2933,226223,00.htmlPosted October 31, 2006. [Accessed August 23, 2007]
  3. Dlugosz L, Bracken MB. Reproductive effects of caffeine: a review and theoretical analysis. Epidemiol Rev. 1992;14:83–100
  4. Gilbert R, Marshman J, Schwieder M, et al. Caffeine content of beverages as consumer. Can Med Assoc J. 1976;114:205–208
  5. Nawrot P, Jordan S, Eastwood J, et al. Effects of caffeine on human health. Food Addit Contam. 2003;20:1–30
  6. Benowitz NL. Clinical pharmacology of caffeine. Annu Rev Med. 1990;41:277–288
  7. Ellison R, Singer M, Moore L, et al. Current caffeine intake of young children: amount and sources. J Am Diet Assoc. 1995;95:802–804
  8. Hughes JR, Oliveto AH. A systematic survey of caffeine intake in Vermont. Exp Clin Psychopharmacol. 1997;5:393–398
  9. Health Canada . It's your health: caffeine. Available at: http://www.hc-sc.gc.ca/iyh-vsv/food-aliment/caffeine_e.htmlPosted February 2006. Updated September 2007. [Accessed September 10, 2007]
  10. McCusker RR, Goldberger BA, Cone EJ. Caffeine content of energy drinks, carbonated sodas, and other beverages. J Anal Toxicol. 2006;30:112–114
  11. Henman AR. Guarana (Paullinia cupana var. sorbilis): ecological and social perspectives on an economic plant of the central Amazon basin. J Ethnopharmacol. 1982;6:311–338
  12. Guarana. In: AltMedDex System [intranet database]. Greenwood Village CVG (Colo): Thomson Micromedex; 2007. Available at:http://www.micromedex.com/products.altm.de.
  13. Food Safety Promotion of Board . A review of the health effects of stimulant drinks: a final report from the Food Safety Promotion Board. Available at: www.safefoodonline.com/article.asp?article=236[Accessed September 14, 2007]
  14. Haskell CF, Kennedy DO, Wesnes KA, et al. A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guarana in humans. J Psychopharmacol. 2007;21:65–70
  15. Brosnan JT, Brosnan ME. The sulfur-containing amino acids: an overview. J Nutr. 2006;136(6 Suppl):1636S–1640S
  16. Stapleton PP, Charles RP, Redmond HP, et al. Taurine and human nutrition. Clin Nutr. 1997;16:103–108
  17. Heird WC. Taurine in neonatal nutrition—revisited. Arch Dis Child Fetal Neonatal Ed. 2004;89:F473–F474
  18. MacDonald ML, Rogers QR, Morris JG. Nutrition of the domestic cat, a mammalian carnivore. Annu Rev Nutr. 1984;4:521–562
  19. Coon JT, Ernst E. Panax ginseng: a systematic review of adverse effects and drug interactions. Drug Saf. 2002;25:323–344
  20. Ernst E. The risk-benefit profile of commonly used herbal therapies: Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava. Ann Intern Med. 2002;136:42–53
  21. Dega H, Laporte JL, Frances C, et al. Ginseng as a cause for Stevens-Johnson syndrome. Lancet. 1996;347:1344
  22. Ries CA, Sahud MA. Agranulocytosis caused by Chinese herbal medicines. Dangers of medications containing aminopyrine and phenylbutazone. JAMA. 1975;231:352–355
  23. Vuksan V, Sievenpiper JL. Herbal remedies in the management of diabetes: lessons learned from the study of ginseng. Nutr Metab Cardiovasc Dis. 2005;15:149–160
  24. Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm. 1997;54:692–693
  25. Siegel RK. Ginseng abuse syndrome. Problems with the panacea. JAMA. 1979;241:1614–1615
  26. Braganza S, Larkin M. Riding high on energy drinks. Modern medicine. Available at: http://www.modernmedicine.com/modernmedicine/article/articleDetail.jsp?id=426763Posted May 15, 2007. [Accessed September 15, 2007]
  27. Lheureux PE, Penaloza A, Zahir S, Gris M. Science review: carnitine in the treatment of valproic acid-induced toxicity—what is the evidence?. Crit Care. 2005;9:431–440
  28. Russell S. Carnitine as an antidote for acute valproate toxicity in children. Curr Opin Pediatr. 2007;19:206–210
  29. Carnitor . Carnitor (levocarnitine) tablets and oral solution, and Carnitor SF sugar-free oral solution package insert. Available at: http://www.carnitormetabolic.com/[Accessed on September 20, 2007]
  30. Soop M, Bjorkman O, Cederblad G, et al. Influence of carnitine supplementation on muscle substrate and carnitine metabolism during exercise. J Appl Physiol. 1988;64:2394–2399
  31. Decombaz J, Gmuender B, Sierro G, et al. Muscle carnitine after strenuous endurance exercise. J Appl Physiol. 1992;72:423–427
  32. Brass E. Supplemental carnitine and exercise. Am J Clin Nutr. 2000;72:618s–623s
  33. Bodybuilding.com . l-Carnitine information and product listing: an amino acid that helps with fat loss. Available at http://www.bodybuilding.com/store/lcarn.html[Accessed September 20, 2007]
  34. Arnaud MJ. The pharmacology of caffeine. Prog Drug Res. 1987;31:273–313
  35. Sawynok J, Yaksh TL. Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action. Pharmacol Rev. 1993;45:43–85
  36. Tyrala EE, Dodson WE. Caffeine secretion into breast milk. Arch Dis Child. 1979;54:787–800
  37. Berger A. Effects of caffeine consumption on pregnancy outcome. A review. J Reprod Med. 1988;33:945–956
  38. Baselt RC. Disposition of toxic drugs and chemicals in man. 5th ed.. Foster City: Chemical Toxicology Institute; 2000;
  39. Fligner CL, Opheim KE. Caffeine and its dimethylxanthine metabolites in two cases of caffeine overdose: a cause of falsely elevated theophylline concentrations in serum. J Anal Toxicol. 1988;12:339–343
  40. Aranda JV, Collinge JM, Zinman R, et al. Maturation of caffeine elimination in infancy. Arch Dis Child. 1979;54:946–949
  41. Eskenazi B, Fenster L, Swan S, et al. Caffeine use during pregnancy: how much is safe?. JAMA. 1993;270:47;[author reply 47-8]
  42. Hinds TS, West WL, Knight EM, et al. The effect of caffeine on pregnancy outcome variables. Nutr Rev. 1996;54:203–207
  43. Karen G. Caffeine during pregnancy? In moderation. Can Fam Phys. 2000;46:801–803
  44. Denaro CP, Wilson M, Jacob P, et al. The effect of liver disease on urine caffeine metabolite ratios. Clin Pharmacol Ther. 1996;59:624–635
  45. Nix DE, Di Cicco RA, Miller AK, et al. The effect of low-dose cimetidine (200 mg twice daily) on the pharmacokinetics of theophylline. J Clin Pharmacol. 1999;39:855–865
  46. Brown CR, Jacob P, Wilson M, et al. Changes in rate and pattern of caffeine metabolism after cigarette abstinence. Clin Pharmacol Ther. 1988;43:488–491
  47. Fredholm BB. On the mechanism of action of theophylline and caffeine. Acta Med Scand. 1985;217:149–153
  48. Vestal RE, Thummel KE, Musser B, et al. Cimetidine inhibits theophylline clearance in patients with chronic obstructive pulmonary disease: a study using stable isotope methodology during multiple oral dose administration. Br J Clin Pharmacol. 1983;15:411–418
  49. Benowitz NL, Osterloh J, Goldschlager N, et al. Massive catecholamine release from caffeine poisoning. JAMA. 1982;248:1097–1098
  50. Watson WA, Litovitz TL, Rodgers GC, et al. 2004 Annual report of the American Association of Poison Control Centers toxic exposure surveillance system. Am J Emerg Med. 2005;23:589–666
  51. Lai MW, Klein-Schwartz W, Rodgers GC, et al. 2005 Annual report of the American Association of Poison Control Centers' national poisoning and exposure database. Clin Toxicol (Phila). 2006;44:803–932
  52. Cannon ME, Cooke CT, McCarthy JS. Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products. Med J Aust. 2001;174:520–521
  53. Alford C, Cox H, Wescott R. The effects of red bull energy drink on human performance and mood. Amino Acids. 2001;21:139–150
  54. Reyner LA, Horne JA. Efficacy of a ‘functional energy drink’ in counteracting driver sleepiness. Physiol Behav. 2002;75:331–335
  55. Horne JA, Reyner LA. Beneficial effects of an “energy drink” given to sleepy drivers. Amino Acids. 2001;20:83–89
  56. Hering-Hanit R, Gadoth N. Caffeine-induced headache in children and adolescents. Cephalalgia. 2003;23:332–335
  57. Millichap JG, Yee MM. The diet factor in pediatric and adolescent migraine. Pediatr Neurol. 2003;28:9–15
  58. Pollak CP, Bright D. Caffeine consumption and weekly sleep patterns in US seventh-, eighth-, and ninth-graders. Pediatrics. 2003;111:42–46
  59. Karacan I, Thornby JI, Anch M, et al. Dose-related sleep disturbances induced by coffee and caffeine. Clin Pharmacol Ther. 1976;20:682–689
  60. Caffeine . In POISINDEX System. Thomson Micromedex. Available at: http://www.thomsonhc.com[Accessed July 19, 2007]
  61. Rivenes SM, Bakerman PR, Miller MB. Intentional caffeine poisoning in an infant. Pediatrics. 1997;99:736–738
  62. Chopra A, Morrison L. Resolution of caffeine-induced complex dysrhythmia with procainamide therapy. J Emerg Med. 1995;13:113–117
  63. Hoffman R. Methylxanthines. In:  Goldfrent LE,  Flomenbaum NE,  Lewin NA, et al. editor. Goldfrank's toxicologic emergencies. 8th ed.. New York (NY): McGraw-Hill; 2006;
  64. Iyadurai SJ, Chung SS. New-onset seizures in adults: possible association with consumption of popular energy drinks. Epilepsy Behav. 2007;10:504–508
  65. Josephson GW, Stine RJ. Caffeine intoxication: a case of paroxysmal atrial tachycardia. JACEP. 1976;5:776–778
  66. Forman J, Aizer A, Young CR. Myocardial infarction resulting from caffeine overdose in an anorectic woman. Ann Emerg Med. 1997;29:178–180
  67. Shum S, Seale C, Hathaway D, et al. Acute caffeine ingestion fatalities: management issues. Vet Hum Toxicol. 1997;39:228–230
  68. Baylin A, Hernandez-Diaz S, Kabagambe EK, et al. Transient exposure to coffee as a trigger of a first nonfatal myocardial infarction. Epidemiology. 2006;17:506–511
  69. Dietrich AM, Mortensen ME. Presentation and management of an acute caffeine overdose. Pediatr Emerg Care. 1990;6:296–298
  70. Perrin C, Debruyne D, Lacotte J, et al. Treatment of caffeine intoxication by exchange transfusion in a newborn. Acta Paediatr Scand. 1987;76:679–681
  71. Walsh I, Wasserman GS, Mestad P, et al. Near-fatal caffeine intoxication treated with peritoneal dialysis. Pediatr Emerg Care. 1987;3:244–249
  72. Mrvos RM, Reilly PE, Dean BS, et al. Massive caffeine ingestion resulting in death. Vet Hum Toxicol. 1989;31:571–572
  73. Maughan R, Griffin J. Caffeine ingestion and fluid balance: a review. J Hum Nutr Diet. 2003;16:411–420
  74. Emohare O, Ratnam V. Multiple cardiac arrests following an overdose of caffeine complicated by penetrating trauma. Anaesthesia. 2006;61:54–56
  75. Wrenn KD, Oschner I. Rhabdomyolysis induced by a caffeine overdose. Ann Emerg Med. 1989;18:94–97
  76. Appel CC, Myles TD. Caffeine-induced hypokalemic paralysis in pregnancy. Obstet Gynecol. 2001;97(5 Pt 2):805–807
  77. Leson CL, McGuigan MA, Bryson SM. Caffeine overdose in an adolescent male. J Toxicol Clin Toxicol. 1988;26:407–415
  78. Arimori K, Nakano M. Transport of theophylline from blood to the intestinal lumen following i.v. administration to rats. J Pharmacobiodyn. 1985;8:324–327
  79. Shannon M, Amitai Y, Lovejoy FH. Multiple dose activated charcoal for theophylline poisoning in young infants. Pediatrics. 1987;80:368–370
  80. Golej J, Boigner H, Burda G, et al. Severe respiratory failure following charcoal application in a toddler. Resuscitation. 2001;49:315–318
  81. Graff GR, Stark J, Berkenbosch JW, et al. Chronic lung disease after activated charcoal aspiration. Pediatrics. 2002;109:959–961
  82. Woo OF, Pond SM, Benowitz NL, et al. Benefit of hemoperfusion in acute theophylline intoxication. J Toxicol Clin Toxicol. 1984;22:411–424
  83. Nagesh RV, Murphy KA. Caffeine poisoning treated by hemoperfusion. Am J Kidney Dis. 1988;12:316–318
  84. Holstege CP, Hunter Y, Baer AB, et al. Massive caffeine overdose requiring vasopressin infusion and hemodialysis. J Toxicol Clin Toxicol. 2003;41:1003–1007
  85. Biberstein MP, Ziegler MG, Ward DM. Use of beta-blockade and hemoperfusion for acute theophylline poisoning. West J Med. 1984;141:485–490
  86. Price K, Fligner D. Treatment of caffeine toxicity with esmolol. Ann Emerg Med. 1990;19:44–46
  87. Whitehurst VE, Joseph X, Vick JA, et al. Reversal of acute theophylline toxicity by calcium channel blockers in dogs and rats. Toxicology. 1996;110:113–121
  88. American Heart Association . Guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2005;112(24 Supplement):
  89. Strubelt O, Diederich KW. Experimental treatment of the acute cardiovascular toxicity of caffeine. J Toxicol Clin Toxicol. 1999;37:29–33
  90. Rudy DR, Lee S. Coffee and hypokalemia. J Fam Pract. 1988;26:679–680
  91. Shannon M. Hypokalemia, hyperglycemia and plasma catecholamine activity after severe theophylline intoxication. J Toxicol Clin Toxicol. 1994;32:41–47
  92. Goldberg MJ, Spector R, Miller G. Phenobarbital improves survival in theophylline-intoxicated rabbits. J Toxicol Clin Toxicol. 1986;24:203–211
  93. Marquis JF, Carruthers SG, Spence JD, et al. Phenytoin-theophylline interaction. N Engl J Med. 1982;307:1189–1190
  94. Blake KV, Massey KL, Hendeles L, et al. Relative efficacy of phenytoin and phenobarbital for the prevention of theophylline-induced seizures in mice. Ann Emerg Med. 1988;17:1024–1028
  95. Hoffman A, Pinto E, Gilhar D. Effect of pretreatment with anticonvulsants on theophylline-induced seizures in the rat. J Crit Care. 1993;8:198–202
  96. Kamijo Y, Soma K, Asari Y, et al. Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia. Vet Hum Toxicol. 1999;41:381–383
  97. Bernstein GA, Carroll ME, Dean NW, et al. Caffeine withdrawal in normal school-age children. J Am Acad Child Adolesc Psychiatry. 1998;37:858–865
  98. Griffiths RR, Woodson PP. Caffeine physical dependence: a review of human and laboratory animal studies. Psychopharmacology (Berl). 1988;94:437–451
  99. CBS News . Study: Red Bull won't tame booze. Available at: http://www.cbsnews.com/stories/2006/03/27/health/webmd/main1443856.shtml.Posted March 27, 2006 [Accessed August 25, 2007]
  100. Ferreira SE, de Mello MT, Pompeia S, et al. Effects of energy drink ingestion on alcohol intoxication. Alcohol Clin Exp Res. 2006;30:598–605
  101. Bernstein GA, Carroll ME, Thuras PD, et al. Caffeine dependence in teenagers. Drug Alcohol Depend. 2002;66:1–6
  102. Ogawa N, Ueki H. Clinical importance of caffeine dependence and abuse. Psychiatry Clin Neurosci. 2007;61:263–268
  103. Strain EC, Mumford GK, Silverman K, et al. Caffeine dependence syndrome. Evidence from case histories and experimental evaluations. JAMA. 1994;272:1043–1048
  104. Swanson JA, Lee JW, Hopp JW. Caffeine and nicotine: a review of their joint use and possible interactive effects in tobacco withdrawal. Addict Behav. 1994;19:229–256

PII: S1522-8401(07)00099-7

doi: 10.1016/j.cpem.2007.12.002

Clinical Pediatric Emergency Medicine
Volume 9, Issue 1 , Pages 35-42 , March 2008